GAME GENIE CODES: Sonic 2 & Knuckles. |
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| No. | Code | Effect |
| 1 | AX6D-AA3W | Knuckles doesn't lose rings when hit |
| 2 | HWLX-GA2Y | Infinite time |
| 3 | SD5X-BJT2 | Rings worth 2 |
| 4 | SD5X-BNT2 | Rings worth 3 |
| 5 | SD5X-BTT2 | Rings worth 4 |
| 6 | SD5X-BYT2 | Rings worth 5 |
| 7 | SD5X-B2T2 | Rings worth 6 |
| 8 | SD5X-B6T2 | Rings worth 7 |
| 9 | SD5X-BAT2 | Rings worth 8 |
| 10 | AE5X-AAFY | Knuckles starts with 1 life instead of 3 |
| 11 | AY5X-AAFY | Knuckles starts with 5 lives |
| 12 | A65X-AAFY | Knuckles starts with 7 lives |
| 13 | BE5X-AAFY | Knuckles starts with 9 lives |
| 14 | DE5X-AAFY | Knuckles starts with 25 lives |
| 15 | GJ5X-AAFY | Knuckles starts with 50 lives |
| 16 | KN5X-AAFY | Knuckles starts with 75 lives |
| 17 | NN5X-AAFY | Knuckles starts with 99 lives |
| 18 | JV1D-CA6W | Infinite lives |
| 19 | PVWD-CRDC | High jump for Knuckles |
| 20 | ABWD-CWDC | Super jump for Knuckles |
| 21 | ABWD-C2DC | Mega jump for Knuckles |
| 22 | ABWD-DTDC | Orbital jump for Knuckles |